Dynamical-Corrected Nonadiabatic Geometric Quantum Computation

Recently, nonadiabatic geometric quantum computation has been received great attentions, due to its fast operation and intrinsic error resilience. However, compared with the corresponding dynamical gates, the robustness of implemented nonadiabatic geometric gates based on the conventional single-loop scheme still has the same order of magnitude due to the requirement of strict multi-segment geometric controls, and the inherent geometric fault-tolerance characteristic is not fully explored. Here, we present an effective geometric scheme combined with a general dynamical-corrected technique, with which the super-robust nonadiabatic geometric quantum gates can be constructed over the conventional single-loop and two-loop composite-pulse strategies, in terms of resisting the systematic error, i.e., $\sigma_x$ error. In addition, combined with the decoherence-free subspace (DFS) coding, the resulting geometric gates can also effectively suppress the $\sigma_z$ error caused by the collective dephasing. Notably, our protocol is a general one with simple experimental setups, which can be potentially implemented in different quantum systems, such as Rydberg atoms, trapped ions and superconducting qubits. These results indicate that our scheme represents a promising way to explore large-scale fault-tolerant quantum computation.Comment: 10 pages, 9 figure

THE COMPARATIVE STUDY ON EXPECTED TOTAL QUALITY COST BETWEEN TRADITIONAL SINGLE SAMPLING PLAN AND ECONOMICAL DESIGN

In the quality inspection practice of the consumer electronics industry, MIL-STD-105E sampling table is viewed as the basis for sampling plans. This traditional quality inspection plan determine the sample size and reject rule based on the size of lot, consumer�s and producer's risk and average quality level (AQL). Traditional sampling plan does not consider internal and external quality costs. However, quality costs were considered in many previous researches, but the comparison between traditional and economical design of single sampling plan is rare from now. This paper discusses the sampling test before the receiving inspection which is vendor simulated buyers. Includes the costs of inspection, rework, replacement, and external failure cost are considered. We compare the quality economical design with traditional single sampling plan under the total quality cost. This paper can be regarded as a reference for future studies and practical applications

Sesamin: A Naturally Occurring Lignan Inhibits CYP3A4 by Antagonizing the Pregnane X Receptor Activation

Inconsistent expression and regulation of drug-metabolizing enzymes (DMEs) are common causes of adverse drug effects in some drugs with a narrow therapeutic index (TI). An important cytochrome, cytochrome P450 3A4 (CYP3A4), is predominantly regulated by a nuclear receptor, pregnane X receptor (PXR). Sesamin, a major lignan constituent in sesame seeds and oil, exhibits a variety of biological functions; however, the effect of sesamin on the modulation of CYP3A4 is not well understood. In this study, the effects of sesamin on the PXR-CYP3A4 pathway were characterized, as well as the underlying mechanisms of those effects. Sesamin potently attenuated CYP3A4 induction in a dose-dependent manner by blocking the activation of PXR. The PXR inducer-mediated inhibition of CYP3A4 was further evidenced by the ability of sesamin to attenuate the effects of several PXR ligands in the CYP3A4 reporter assay. Further mechanistic studies showed that sesamin inhibited PXR by interrupting the interacting with coregulators. These results may lead to the development of new therapeutic and dietary approaches to reduce the frequency of inducer-drug interaction. Sesamin was established as a novel inhibitor of PXR and may be useful for modulating DMEs expression and drug efficacies. Modification of CYP3A4 expression and activity by consumption of sesamin may have important implications for drug safety

Ligand-assisted cation-exchange engineering for high-efficiency colloidal Cs1−xFAxPbI3 quantum dot solar cells with reduced phase segregation

The mixed caesium and formamidinium lead triiodide perovskite system (Cs1−xFAxPbI3) in the form of quantum dots (QDs) offers a pathway towards stable perovskite-based photovoltaics and optoelectronics. However, it remains challenging to synthesize such multinary QDs with desirable properties for high-performance QD solar cells (QDSCs). Here we report an effective oleic acid (OA) ligand-assisted cation-exchange strategy that allows controllable synthesis of Cs1−xFAxPbI3 QDs across the whole composition range (x = 0–1), which is inaccessible in large-grain polycrystalline thin films. In an OA-rich environment, the cross-exchange of cations is facilitated, enabling rapid formation of Cs1−xFAxPbI3 QDs with reduced defect density. The hero Cs0.5FA0.5PbI3 QDSC achieves a certified record power conversion efficiency (PCE) of 16.6% with negligible hysteresis. We further demonstrate that the QD devices exhibit substantially enhanced photostability compared with their thin-film counterparts because of suppressed phase segregation, and they retain 94% of the original PCE under continuous 1-sun illumination for 600 h

Interface induced high temperature superconductivity in single unit-cell FeSe films on SrTiO3

Searching for superconducting materials with high transition temperature (TC) is one of the most exciting and challenging fields in physics and materials science. Although superconductivity has been discovered for more than 100 years, the copper oxides are so far the only materials with TC above 77 K, the liquid nitrogen boiling point. Here we report an interface engineering method for dramatically raising the TC of superconducting films. We find that one unit-cell (UC) thick films of FeSe grown on SrTiO3 (STO) substrates by molecular beam epitaxy (MBE) show signatures of superconducting transition above 50 K by transport measurement. A superconducting gap as large as 20 meV of the 1 UC films observed by scanning tunneling microcopy (STM) suggests that the superconductivity could occur above 77 K. The occurrence of superconductivity is further supported by the presence of superconducting vortices under magnetic field. Our work not only demonstrates a powerful way for finding new superconductors and for raising TC, but also provides a well-defined platform for systematic study of the mechanism of unconventional superconductivity by using different superconducting materials and substrates

OMAE2009-79717 A TRUSS SEMISUBMERSIBLE OPTIMIZED FOR THE POST KATRINA ENVIRONMENT IN GULF OF MEXICO CORRELATED WITH MODEL TEST

ABSTRACT This paper presents a Truss Semisubmersible (Truss Semi) design optimized to meet the post-Katrina Gulf of Mexico (GoM) environment criteria, with global performance correlated in 1:50 scale model tests in a wave basin

Elevated thyroglobulin level is associated with dysfunction of regulatory T cells in patients with thyroid nodules

Objective: Thyroid nodules are usually accompanied by elevated thyroglobulin (Tg) level and autoimmune thyroid diseases (AITDs). However, the relationship between Tg and AITDs is not fully understood. Dysfunction of regulatory T cells (Tregs) plays an important role in the development of AITDs. We aimed to evaluate the effects of Tg on the function of Tregs in patients with thyroid nodules. Methods: Tg levels and the functions of Tregs in peripheral blood and thyroid tissues of patients with thyroid nodules from Nanjing First Hospital were evaluated. The effects of Tg on the function of Tregs from healthy donors were also assessed in vitro. The function of Tregs was defined as an inhibitory effect of Tregs on the effector T cell (CD4+ CD25− T cell) proliferation rate. Results: The level of Tg in peripheral blood correlated negatively with the inhibitory function of Tregs (R = 0.398, P = 0.03), and Tregs function declined significantly in the high Tg group (Tg >77 μg/L) compared with the normal Tg group (11.4 ± 3.9% vs 27.5 ± 3 .5%, P < 0.05). Compared with peripheral blood, the function of Tregs in thyroid declined significantly (P < 0.01), but the proportion of FOXP3+ Tregs in thyroid increased (P < 0.01). High concentration of Tg (100 μg/mL) inhibited the function of Tregs and downregulated FOXP3, TGF-β and IL-10 mRNA expression in Tregs in vitro. Conclusions: Elevated Tg level could impair the function of Tregs, which might increase the risk of AITDs in patient with thyroid nodules